A 2017 surge in e-cigarette gross sales is related to the introduction of a high-nicotine e-cigarette manufactured by JUUL.
More than 1 million United States youth aged 14 to 17 years previous in 2017 turned new every day tobacco customers inside two years. By 2019, greater than three quarters of those youths have been vaping e-cigarettes every day.
Appearing within the May 30, 2022 on-line version of Pediatrics, University of California San Diego researchers report that JUUL Labs disrupted the e-cigarette market after they launched the primary excessive nicotine e-cigarette, a smooth product with sweet and fruit flavorings.
In 2017, there was a 40% surge in e-cigarette gross sales within the United States, pushed by JUUL merchandise. The U.S. surgeon common labeled it an epidemic of youth vaping. The researchers present this was additionally accompanied by a rise in new every day tobacco use, with 64.6% of latest customers occurring amongst youths aged 14 to 17.

John P. Pierce, Ph.D., Distinguished Professor on the UC San Diego Herbert Wertheim School of Public Health and Human Longevity Science, and UC San Diego Moores Cancer Center
“Our analysis translates to 2,284 new underaged daily tobacco users each day between 2017 and 2019. This rate of youth tobacco initiation has not been seen since the early 1990s, prior to the implementation of tobacco control measures,” stated co-author John P. Pierce, Ph.D., Distinguished Professor on the UC San Diego Herbert Wertheim School of Public Health and Human Longevity Science, and UC San Diego Moores Cancer Center.
“Given the recent evidence of the potential health consequences of vaping flavored e-cigarettes, this sharp rise among youth requires urgent public health attention and action.”
Using knowledge from the nationally consultant Population Assessment of Tobacco and Health (PATH) longitudinal examine, undertaken by the National Institute on Drug Abuse and the FDA Center for Tobacco Products underneath contract with Westat, researchers assessed two cohorts of youth and younger adults ages 14 to 34 years: one with baseline survey knowledge in 2014 earlier than the surge of JUUL merchandise, and the opposite in 2017 because the surge in JUUL gross sales was occurring.
For 5 age teams, the researchers in contrast what number of contributors used tobacco for the primary time and what number of turned every day tobacco customers over a two-year interval.
Although the comparability of the 2014 cohort to the 2017 group exhibits a drop within the variety of people who tried cigarette smoking or who turned every day cigarette people who smoke, general every day tobacco utilization elevated led by an increase in every day e-cigarette vaping, significantly amongst these aged 14 to 17.
Among the 2017 cohort, these aged 14 to 17 had a 3.6-fold larger price of development to every day e-cigarette in comparison with the 2014 cohort, and two-thirds of all new every day tobacco customers have been aged 14 to 17 years.
Furthermore, underaged new every day e-cigarette vapers had tobacco dependence scores that have been much like these of latest every day cigarette people who smoke.
E-cigarettes — battery-operated gadgets that warmth a liquid manufactured from nicotine, flavorings and different chemical compounds to make an aerosol that customers inhale into their lungs — have been first offered within the United States in 2007. An April 2022 study in eLife led by researchers at UC San Diego School of Medicine signifies these non-traditional cigarettes have important potential for later well being penalties.
In 2017, gross sales within the U.S. skyrocketed. Juul merchandise led the best way with youth-appealing flavors and the introduction of excessive nicotine concentrations, offering customers with comparable blood nicotine concentrations to conventional cigarette people who smoke. The researchers estimate that 600,000 people within the U.S. underneath 21 used JUUL merchandise every day in 2019, a price 2.5-times larger than these aged 25 to 34. Previous analysis had demonstrated that in 2017, JUUL products were not used by US smokers trying to quit smoking.

Karen Messer, Ph.D., professor of biostatistics on the Herbert Wertheim School of Public Health
“Three major contributors influenced the increase in daily e-cigarette usage: social media campaigns, high nicotine concentrations, and fruit flavors,” stated senior creator Karen Messer, Ph.D., professor of biostatistics on the Herbert Wertheim School of Public Health. “Our prior research indicates that it is very difficult for dependent tobacco users to quit, with many e-cigarette users converting to cigarette smoking. This surge in dependent e-cigarette vaping may be reversing decades of decline in rates of tobacco addiction.”
In January 2020, the U.S. Food and Drug Administration introduced a ban on most flavorings in cartridge e-cigarettes. However, the coverage didn’t embody disposable e-cigarettes, e-liquids, or refillable gadgets. The FDA is within the public remark stage for a proposed rule prohibiting menthol cigarettes and flavored cigars.
In 2021, there have been an estimated 1.7 million excessive school-aged vapers with 85% utilizing flavored merchandise. JUUL, which had eliminated all fruit and sweet flavorings on the behest of the FDA in 2019, was not the market chief. More than half of highschool vapers now used high-nicotine, flavored, disposable gadgets, wrote the researchers.
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Co-authors embody: Jasen Zhang, Laura E. Crotty Alexander, Eric C. Leas, Sheila Kealey, Martha M. White, David R. Strong, Dennis R. Trinidad, Sara B. McMenamin, Ruifeng Chen, and Tarik Benmarhnia, all of UC San Diego.
This analysis was funded, partly, by the National Institutes of Health (R01CA234539) and the Tobacco-Related Disease Research Program of the University of California, Office of the President (28IR-0066; T31IR-1584; T30IP-0965).
Disclosures: The authors don’t have any conflicts to report.
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