Statins are a category of medication that decrease levels of cholesterol within the blood. They work by blocking an enzyme within the liver that’s accountable for producing ldl cholesterol.
Recent analysis hyperlinks the cholesterol-lowering medication to a decrease threat of bleeding stroke.
According to current analysis people who use statins, a category of medication that lower levels of cholesterol might have a decreased threat of an intracerebral hemorrhage. Intracerebral hemorrhage is a kind of stroke brought on by bleeding within the mind. The examine was lately printed within the journal Neurology.
“While statins have been shown to reduce the risk of stroke from blood clots, there has been conflicting research on whether statin use increases or decreases the risk of a person having a first intracerebral hemorrhage,” stated examine writer David Gaist, MD, Ph.D., of the University of Southern Denmark in Odense and a member of the American Academy of Neurology. “For our study, we looked at the lobe and non-lobe areas of the brain to see if the location was a factor for statin use and the risk of a first intracerebral hemorrhage. We found that those who used a statin had a lower risk of this type of bleeding stroke in both areas of the brain. The risk was even lower with long-term statin use.”
The lobe space of the mind contains most of the cerebrum, together with the frontal, parietal, temporal, and occipital lobes. The non-lobe space primarily contains the basal ganglia, thalamus, cerebellum, and brainstem.
For the examine, researchers checked out well being data in Denmark and recognized 989 individuals with a median age of 76 who had an intracerebral hemorrhage within the lobe space of the mind. They had been in comparison with 39,500 individuals who didn’t have this kind of stroke and had been related in age, intercourse, and different components.
They additionally checked out 1,175 individuals with a median age of 75 who had an intracerebral hemorrhage within the non-lobe components of the mind. They had been in comparison with 46,755 individuals who didn’t have this kind of stroke and had been related in age, intercourse, and different components.
Researchers used prescription information to find out data on statin use.
Of the whole members, 6.8% who had a stroke had been taking statins for 5 or extra years, in comparison with 8.6% of those that didn’t have a stroke.
After adjusting for components like hypertension, diabetes, and alcohol use, researchers discovered that folks at present utilizing statins had a 17% decrease threat of having a stroke within the lobe areas of the mind and a 16% decrease threat of stroke within the non-lobe areas of the mind.
Longer use of statins was related to a decrease threat of stroke in each areas of the mind. When utilizing statins for greater than 5 years, individuals had a 33% decrease threat of having a stroke within the lobe space of the mind and a 38% decrease threat of stroke within the non-lobe space of the mind.
“It’s reassuring news for people taking statins that these medications seem to reduce the risk of bleeding stroke as well as the risk of stroke from blood clots,” Gaist added. “However, our research was done in only the Danish population, which is primarily people of European ancestry. More research should be conducted in other populations.”
Reference: “Association Between Statin Use and Intracerebral Hemorrhage Location: A Nested Case-Control Registry Study” by Nils Jensen Boe, Stine Munk Hald, Mie Micheelsen Jensen, Jonas Asgaard Bojsen, Mohammad Talal Elhakim, Sandra Florisson, Alisa Saleh, Anne Clausen, Sören Möller, Frederik Severin Gråe Harbo, Ole Graumann, Jesper Hallas, Luis Alberto García Rodríguez, Rustam Al-Shahi Salman, Larry B. Goldstein and David Gaist, 7 December 2022, Neurology.
DOI: 10.1212/WNL.0000000000201664
The examine was funded by the Novo Nordisk Foundation.
